This may sound a little naïve, but would it be useful & practical for all EQA schemes to provide the reference or definitive value when collating reports? We would then have more idea of the "true" value to which we are aspiring and which methods are closest to the "true" value. Occasionally, the group spread may be quite wide and assuming the group mean or all methods mean to be the "true" value may lead to misleading conclusions. Subsequent market forces may also drive manufacturers to focus on measuring as close to the "true" value as possible.
(I hope to be educated as a result of these comments as I am sure I may have the wrong end of the stick!)
Chris
-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Dave Ducroq
Sent: 07 September 2006 15:36
To: [log in to unmask]
Subject: Re: Clinical transferability of reports
I fully agree with the sentiment in this thread. As a UK EQA provider,
WEQAS has been committed for some time to providing traceable reference
targets for many of the schemes. As part of the organisation, we have a
Reference Laboratory that is part of the European Network of Reference
laboratories. The IFCC LDH reference enzyme assays is used to target all
of our General Chemistry samples sent by WEQAS. This method, along with
other Reference Methods (electrolytes, steroids, creatinine, bile
acids), has been registered with the JCTLM. In addition to LDH, GGT is
also targeted in all samples and AST is currently in the validation
stage and will be added soon.
David Ducroq
Deputy Director
Quality Laboratories
Quadrant Centre
Llanishen
Cardiff
CF14 5WF
Tel 02920 748355
Fax 02920 748336
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Ballieux,
B.E.P.B. (CKCL)
Sent: 05 September 2006 10:14
To: [log in to unmask]
Subject: Re: Clinical transferability of reports
What really makes a difference is to have an IFCC certified enzyme
reference lab working closely with the national EQAS organisation. Then
the fiddling factors will be traceable to referencemethods and will
serve to overcome the flaws of the "CE marked reagents". Than,
hopefully, one day all manufacturers will allign their reagents to the
IFCC reference methods and the fiddling factors will disappear
gradually. This has succeeded in the past with cholesterol, so why not
with LD.
Bart Ballieux
Dr. Ir. B.E.P.B. Ballieux
Clinical Biochemist
Leiden University Medical Centre
P.O. box 9600
2300 RC Leiden
The Netherlands
t: +3171-5262165
f: +3171-5266753
e: [log in to unmask]
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Ian Young
Sent: maandag 4 september 2006 23:59
To: [log in to unmask]
Subject: Re: Clinical transferability of reports
> Needs a strong IFCC push or else we shall all be fiddling with CE
> marked reagent kits on our different analysers in order to achieve
> consensus.
There is a relatively new IFCC working group looking at the issue of
common reference ranges, so hopefully there will be a push in the next
year or two!
Ian Young
IS Young
Professor of Medicine, Queen's University Belfast Consultant Chemical
Pathologist, The Royal Group of Hospitals Director of Research and
Development, The Royal Group of Hospitals
Wellcome Research Laboratories
Top Floor, Mulhouse Building
Royal Victoria Hospital
Grosvenor Road
Belfast BT12 6BJ
Northern Ireland
tel: 0044 2890 632743
fax: 0044 2890 235900
email: [log in to unmask]
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