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This may sound a little naïve, but would it be useful & practical for all EQA schemes to provide the reference or definitive value when collating reports? We would then have more idea of the "true" value to which we are aspiring and which methods are closest to the "true" value. Occasionally, the group spread may be quite wide and assuming the group mean or all methods mean to be the "true" value may lead to misleading conclusions. Subsequent market forces may also drive manufacturers to focus on measuring as close to the "true" value as possible. (I hope to be educated as a result of these comments as I am sure I may have the wrong end of the stick!) Chris -----Original Message----- From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Dave Ducroq Sent: 07 September 2006 15:36 To: [log in to unmask] Subject: Re: Clinical transferability of reports I fully agree with the sentiment in this thread. As a UK EQA provider, WEQAS has been committed for some time to providing traceable reference targets for many of the schemes. As part of the organisation, we have a Reference Laboratory that is part of the European Network of Reference laboratories. The IFCC LDH reference enzyme assays is used to target all of our General Chemistry samples sent by WEQAS. This method, along with other Reference Methods (electrolytes, steroids, creatinine, bile acids), has been registered with the JCTLM. In addition to LDH, GGT is also targeted in all samples and AST is currently in the validation stage and will be added soon. David Ducroq Deputy Director Quality Laboratories Quadrant Centre Llanishen Cardiff CF14 5WF Tel 02920 748355 Fax 02920 748336 -----Original Message----- From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Ballieux, B.E.P.B. (CKCL) Sent: 05 September 2006 10:14 To: [log in to unmask] Subject: Re: Clinical transferability of reports What really makes a difference is to have an IFCC certified enzyme reference lab working closely with the national EQAS organisation. Then the fiddling factors will be traceable to referencemethods and will serve to overcome the flaws of the "CE marked reagents". Than, hopefully, one day all manufacturers will allign their reagents to the IFCC reference methods and the fiddling factors will disappear gradually. This has succeeded in the past with cholesterol, so why not with LD. Bart Ballieux Dr. Ir. B.E.P.B. Ballieux Clinical Biochemist Leiden University Medical Centre P.O. box 9600 2300 RC Leiden The Netherlands t: +3171-5262165 f: +3171-5266753 e: [log in to unmask] -----Original Message----- From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Ian Young Sent: maandag 4 september 2006 23:59 To: [log in to unmask] Subject: Re: Clinical transferability of reports > Needs a strong IFCC push or else we shall all be fiddling with CE > marked reagent kits on our different analysers in order to achieve > consensus. There is a relatively new IFCC working group looking at the issue of common reference ranges, so hopefully there will be a push in the next year or two! Ian Young IS Young Professor of Medicine, Queen's University Belfast Consultant Chemical Pathologist, The Royal Group of Hospitals Director of Research and Development, The Royal Group of Hospitals Wellcome Research Laboratories Top Floor, Mulhouse Building Royal Victoria Hospital Grosvenor Road Belfast BT12 6BJ Northern Ireland tel: 0044 2890 632743 fax: 0044 2890 235900 email: [log in to unmask] ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. 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