I am trying to come up with a comment to send with results showing marginal
elevations (NA <1000 nmol/d and A <200 nmol/d) in urinary free
catecholamines (method = HPLC - ECD with cation exchange/alumina cleanup ).
In particular I am interested in an up to date list of drugs known to
increase catecholamine excretion eg the list so far includes
Amphetamines
Clozapine
Ephedrine
Prazosin
Phentolamine
Metoclopramide
Tricyclic antidepressants
Sinemet/Madopar - dopamine invariably increased.
Adrenalin - administered during the collection can increase adrenaline
Can MAOI and the newer COMTI drugs cause increased catecholamines?
I believe most drugs that increase noradrenaline levels do so by either
blocking reuptake or increasing release but do any cause increases in both
NA and A ?
Aldomet and Labetalol metabolites are well resolved in our assay.
Thanks in advance for your opinion on this matter.
Michael Freemantle
Sullivan Nicolaides Pathology
PO Box 344
Indooroopilly Q4068
Brisbane
Australia 4068
ph +61 (0)7 33778638
fax +61 (0)7 38705989
home page http://www.powerup.com.au/~mfreeman
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
|