 |
 |
I am trying to come up with a comment to send with results showing marginal elevations (NA <1000 nmol/d and A <200 nmol/d) in urinary free catecholamines (method = HPLC - ECD with cation exchange/alumina cleanup ). In particular I am interested in an up to date list of drugs known to increase catecholamine excretion eg the list so far includes Amphetamines Clozapine Ephedrine Prazosin Phentolamine Metoclopramide Tricyclic antidepressants Sinemet/Madopar - dopamine invariably increased. Adrenalin - administered during the collection can increase adrenaline Can MAOI and the newer COMTI drugs cause increased catecholamines? I believe most drugs that increase noradrenaline levels do so by either blocking reuptake or increasing release but do any cause increases in both NA and A ? Aldomet and Labetalol metabolites are well resolved in our assay. Thanks in advance for your opinion on this matter. Michael Freemantle Sullivan Nicolaides Pathology PO Box 344 Indooroopilly Q4068 Brisbane Australia 4068 ph +61 (0)7 33778638 fax +61 (0)7 38705989 home page http://www.powerup.com.au/~mfreeman %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%