Yes, aspartame the sweet poison. Ban all diet foods & drinks, they say!!!
Mohammad
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On Thu, 11/9/14, Jonathan Kay <[log in to unmask]> wrote:
Subject: Re: It's not Friday, or Apr 1st but...
To: [log in to unmask]
Date: Thursday, 11 September, 2014, 10:41
What was wrong with her? Metabolic acidosis?
Did you really do that in mass units? And
"dl"?
Jonathan
On 11 Sep 2014, at 10:28,
Reynolds Tim (RJF) BHFT <[log in to unmask]>
wrote:
I have just had a really interesting argument
with an ITU physician who wanted a serum methanol analysed.
Reason for request: We believe the patient is ill because of
the diet coke she is drinking!
Eventually, I had to promise to look at the
science of aspartame metabolism to prove that there was no
reason to measure methanol. So, for the benefit of the
hive:
Diet drinks contain enough aspartame to
release approx 56mg methanol / L.
Healthy adults can consume 800mg methanol /
hour without showing any change in methanol or formate
concentration in serum [i.e.
non-detectable].
A single dose of 37mg/kg methanol gives
undetectable levels.
At 100 mg/kg methanol reaches a peak
concentration of 1.27 mg/dl.
Therefore for this 63 kg patient, and
assuming that all of the diet coke was consumed in one
(short / instantaneous) session; and that the aspartame was
hydrolysed to release the methanol instantly,
the dose of diet coke required to give measurable methanol
is 112.5 L, which surprising is not quite twice body
weight.
As no one had noticed a tanker of diet coke
being slipped quietly into ITU, and the patient had not been
plumbed in to get rid of the waste, they accepted that this
was a nonsensical hypothesis and
finally agreed not to push for methanol
assay...
NOTE: This is
not quite as much as is required for resveratrol [health
food shop dose 1000mg/capsule; red wine content 0.3 mg/150ml
glass [about 2mg/bottle] - so you have to drink 500L red
wine
/ day to get your resveratrol dose].
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