Concomitant raised serum copper and caeruloplasmin, I think, has no clinical sequalae. However, the authors of this case report think not:
http://www.hindawi.com/journals/jp/2011/385767/
It could be transient and will return back to normal after pregnancy.
Regards
Mohammad
Dr. M A Al-Jubouri, MB ChB, MSc, EurClinChem, FRCP Edin, FRCPath
Consultant Chemical Pathologist
--------------------------------------------
On Thu, 18/9/14, Neil Greig <[log in to unmask]> wrote:
Subject: Elevated copper case
To: [log in to unmask]
Date: Thursday, 18 September, 2014, 17:01
Dear all
We have recently had a case of a 28 year old pregnant lady
(15 weeks) with a significantly elevated serum copper (59
umol/L). The zinc and selenium levels in blood were slightly
low (zinc 9 umol/L and 0.86 umol/L). This has been
confirmed on a second sample to exclude contamination. Her
caeruloplasmin is moderately elevated (0.72 g/L) in keeping
with her pregnancy. These investigations were undertaken due
to abnormal liver function tests, which were not thought to
be pregnancy related and have now resolved. She has
hyperthyroidism, with her last TFT results of TSH <0.1
mU/L, FT4 23 pmol/L and FT3 of 8.6 pmol/L. We added a CRP to
exclude significant acute phase response, which was 15 g/L.
We understand that the patient is asymptomatic, of
Vietnamese origin and is new to our area but not the UK. She
has denied taking any supplements, traditional remedies etc
or unusual eating habits with no obvious occupational
exposure. She has had a vague history of previous liver
issues but we don’t have any further specific details. We
understand that she has lost two previous pregnancies.
The elevation of copper does not seem to fit with the
gestation of pregnancy or clinical picture. Has anyone come
across a similar case or have any ideas?
Many thanks
Neil
Neil Greig PhD FRCPath
Principal Clinical Scientist
Clinical Pathology
Queens Medical Centre
Nottingham University Hospitals
Neil Greig PhD FRCPath
Principal Clinical Scientist
Clinical Pathology
Queens Medical Centre
Nottingham University Hospitals
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