We measure copper and caeruloplasmin on all requests and report the free
copper. It is possible for Wilson's Disease to have low/normal copper
and caeruloplasmin concentrations. There is no 'cut off' for free
copper concentration in Wilson's Disease or heterozygotes. Urine copper
is probably the best test for Wilson's Disease, with a follow up of a
penicillamine chelation test if this is borderline.
Barry
Barry Sampson
Principal Biochemist and Honorary Lecturer
Trace Element Laboratory
Clinical Chemistry
Charing Cross Hospital & Imperial College School of Medicine
London
W6 8RF UK
Phone +44-020-8383 3644
Fax +44-020-8846-7007
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Stuart Jones
Sent: Tuesday, March 21, 2006 5:30 PM
To: [log in to unmask]
Subject: Ceruloplasmin and Wilson's disease
Dear Mailbase users,
I am currently auditing Ceruloplasmin and copper data in our lab. I am
quite interested to know how other labs interpret results on patient's
being investigated for Wilson's Disease.
We currently refer samples with Ceruloplasmin <250mg/L for serum copper
analysis from which we calculate a free copper index. We then suggest
24Hr
Urine copper if free copper >25%.
What approach do other labs take? Are there any guidelines I should know
about? I appreciate any information anyone can offer me on the subject.
Thanks in advance
Stuart Jones
Trainee Clinical Biochemist
Derbyshire hospitals
Derby
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------ACB discussion List Information--------
This is an open discussion list for the academic and clinical
community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
via the internet. Views expressed are those of the individual and
they are responsible for all message content.
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