Thank you for your letter Joseph
I have not received the complete text yet
If you will you go to the AACC Chicago meeting in the end of July we can
meet there
Kind regards
Nils
> yes nils, it does interest me
>
> many thanks
>
> Dr Joseph Watine, PH, AIHP, PharmD, AAHU, EurClinChem
> Laboratoire de Biologie Polyvalente
> Centre Hospitalier Général
> 12027 Rodez Cedex 9
> France
>
>
>>From: "Nils Tryding" <[log in to unmask]>
>>Reply-To: [log in to unmask]
>>To: "Joseph WATINE" <[log in to unmask]>
>>Subject: Re: false positive results for urine opiates
>>Date: Fri, 30 Jun 2006 15:58:12 +0200 (CEST)
>>
>>Yes Joseph you are wright.
>>Perhaps this recent article might interest you
>>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=abstract&list_uids=16776640&query_hl=18&itool=pubmed_docsum
>>Hypothesis on interferences in kinetic interaction of microparticles in
>>solution (KIMS) technology.
>>
>>Giovanni ND, Fucci N.
>>
>>1. Istituto di Medicina Legale e delle Assicurazioni, Universita
>> Cattolica
>>del Sacro Cuore, Rome, Italy.
>>
>>The present paper describes an evaluation of the interferences found with
>>an immunochemical drug test performed during a workplace control. During
>>the period 1993-2003 more than 200,000 urine samples from workers were
>>examined by the Italian Air Force. Samples were screened for drugs of
>>abuse (opiates, cocaine, cannabinoids, amphetamines, methadone) using an
>>immunochemical technique (Roche, kinetic interaction of microparticles in
>>solution, KIMS). A total of 520 positive samples were sent to the
>> Forensic
>>Toxicology Laboratory for confirmation by gas chromatography/mass
>>spectrometry (GC/MS). Approximately 39% of these were found to be true
>>positives. For the remaining samples, pharmacological therapy in subjects
>>was estimated to evaluate possible interferences due to medicine intake.
>>Our study showed a high frequency of false-positive results with this
>>immunochemical technique, mainly for the cannabinoid and amphetamine
>>groups. Recurrent references to some medicines during subject anamnesis
>>were noted. Clin Chem Lab Med 2006;44;894-7.
>>
>>Nils
>>
>>thanks nils,
>> >
>>
>> > please note however that, unless I have not understood this abstract,
>> > Tolmetin caused false négative results, not false positive ones in
>> this
>> > study
>> >
>> > Dr Joseph Watine
>> > Laboratoire de Biologie Polyvalente
>> > Centre Hospitalier Général
>> > Rodez, France
>> >
>> >>From: "Nils Tryding" <[log in to unmask]>
>> >>Reply-To: [log in to unmask]
>> >>To: "Joseph WATINE" <[log in to unmask]>
>> >>CC: [log in to unmask]
>> >>Subject: Re: false positive results for urine opiates
>> >>Date: Fri, 30 Jun 2006 11:06:48 +0200 (CEST)
>> >>
>> >>In our databank DECC
>> >>http://www.tryding.se/drug.htm
>> >>You can also find that Tolmetin can interfere in an EMIT assay
>> >>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=7723297&query_hl=1&itool=pubmed_DocSum
>> >> J Anal Toxicol. 1995 Jan-Feb;19(1):13-7. Related Articles, Links
>> >>Interference by nonsteroidal anti-inflammatory drugs in EMIT and TDx
>> >>assays for drugs of abuse.
>> >>Joseph R, Dickerson S, Willis R, Frankenfield D, Cone EJ, Smith DR.
>> >>
>> >>With kind regards
>> >>Nils
>> >>Nils Tryding MD PhD
>> >>Andreas Björkmans gata 4,
>> >>Box 57, 296 21 Åhus
>> >>[log in to unmask]
>> >>Tel +4644240007
>> >>Fax +4644241260
>> >>Website http://www.tryding.se
>> >>
>> >> > Apart from rifampicine [1,2] and the quinolones [3-5], which other
>> >> > molecules
>> >> > can cause false positive immunoassay results for urine opiates?
>> >>
>> >> >
>> >> > Many thank in advance,
>> >> >
>> >> > Dr Joseph Watine
>> >> > Laboratoire de Biologie Polyvalente
>> >> > Centre Hospitalier Général
>> >> > Rodez, France
>> >> >
>> >> > 1) de Paula M, Saiz LC, Gonzalez-Revalderia J, Pascual T, Alberola
>> C,
>> >> > Miravalles E. Rifampicin causes false-positive immunoassay results
>>for
>> >> > urine
>> >> > opiates. Clin Chem Lab Med 1998 Apr;36(4):241-3.
>> >> >
>> >> > 2) Herrera Trevilla P, Ortiz Jimenez E, Tena T, Lora Tamayo C.
>> >> Presence
>> >>of
>> >> > rifampicin in urine causes cross-reactivity with opiates using the
>> >> KIMS
>> >> > method. J Anal Toxicol 1995 May-Jun;19(3):200.
>> >> >
>> >> > 3) Baden LR, Horowitz G, Jacoby H, Eliopoulos GM. Quinolones and
>> >> > false-positive urine screening for opiates by immunoassay
>> technology.
>> >>JAMA
>> >> > 2001 Dec 26;286(24):3115-9.
>> >> >
>> >> > 4) Zacher JL, Givone DM. False-positive urine opiate screening
>> >>associated
>> >> > with fluoroquinolone use. Ann Pharmacother 2004 Sep;38(9):1525-8.
>>Epub
>> >> > 2004
>> >> > Jul 13.
>> >> >
>> >> > 5) Meatherall R, Dai J. False-positive EMIT II opiates from
>>ofloxacin.
>> >> > Ther Drug Monit 1997 Feb;19(1):98-9.
>
>
>
Nils Tryding MD PhD
Box 57, SE 296 21 Åhus
Tel +4644240007
Fax +4644241260
Website http://www.tryding.se
------ACB discussion List Information--------
This is an open discussion list for the academic and clinical
community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
via the internet. Views expressed are those of the individual and
they are responsible for all message content.
ACB Web Site
http://www.acb.org.uk
List Archives
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
List Instructions (How to leave etc.)
http://www.jiscmail.ac.uk/
|