As described in Valrley's, 6th edition: A 24 h urinary
calcium is inappropriately low (<5 mmol/24h) for
degree of hypercalcaemia. Calcium excretion index
(CaE)can be performed on a 4 h timed urine collection
while the patient is fasting. A blood sample must be
collected during this period.
I always recommend 24 h urinary calcium measurement in
the workup of patients with mild hypercalcaemia to
rule out the possibilty of FHH. Also, serum magnesium
is usually high in such condition compared to primary
hyperparathyroidism and can be useful in
differentiating the two conditions.
Mohammad
--- [log in to unmask] wrote: > I would be
grateful for any advice regarding the use
> of urine samples in
> the diagnosis of this condition. We check up on the
> serum calcium of family
> members in addition to checking the urine calcium of
> the patient.
> Should a 24hr urine collection be used for this in
> the patient or is a
> random urine OK for use in the calculations (should
> the patient fast /
> second void?)
>
> I check using two calculations
>
> Ann Clin Biochem 1992;29:52-58
>
> Ca[E] = Urine Ca x Serum creatinine / Urine
> creatinine(in mmol/l)
>
> and
>
> Ann Int Med 1980;92:351-356
>
> Ca: Creatinine Clearance = Urine Ca x Serum
> creatinine / Urine creatinine x
> Serum calcium
>
> How do others approach this in the patients who need
> to be checked for FHH
> prior to any parathyroid surgery?
>
> Many thanks
>
> Rob
> Dr Robert Lord
> Department of Clinical Biochemistry
> Rotherham District General Hospital
> Moorgate Road
> Oakwood
> Rotherham
> S60 2UD
>
> Tel 01709 820000
>
> E mail [log in to unmask]
>
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Dr. M A Al-Jubouri
Consultant Chemical Pathologist
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------ACB discussion List Information--------
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via the internet. Views expressed are those of the individual and
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