We use TPO antibodies as an adjunct to GP samples in which the TSH is
modestly raised without any history of thyroid disease etc. We then
interpret the data using the Whickham study as a guide. The presence
of positive abs WITH raised TSH predicts the development of
hypothyroidism at a rate of approx 5% per year (it is higher in men
than women but it does at least alert the GPs to those patients who
need long term follow-up (see Clin Endocrinol 1995;43:55-68).
There is a good letter about the usefulness of thyroid antibodies
(anti-TPO, anti-TG, TSH-receptor abs) in thyroid disease in this
months Clinical Endocrinology 1999;50:679-80.
Julian Barth
> We have the opportunity to measure thyroid peroxidase antibodies(TPOAb) =
> locally using Immulite. I would be interested to hear if anyone is =
> operating a cost -effective strategy based on TSH levels or any other =
> criteria. Our endocrinologist remains unconvinced of their value in most =
> new cases and considers that all moderately raised TSH levels should be =
> followed up every 6 to 12 months.
>
> Roy Fisher
> Consultant Biochemist
> Royal Cornwall Hospital
>
> [log in to unmask] or [log in to unmask]
___________________________________________________
Julian H Barth
Department of Chemical Pathology & Immunology
Leeds General Infirmary
Leeds LS1 3EX
tel 0113-392-3416
fax 0113-233-5672
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