> Reply-to: Richard Dixon <[log in to unmask]>
> Forgive me if there is a simple explanation to this question, but is
anyone
> aware of a connection between hypothyroidism and hypophosphataemia ?
> Could diminished bone turnover be involved somehow ??
Serum phosphate is not generally found to be different in patients
with either hypothyroidism or hyperthyroidism, and does not change
much following thyroxine therapy. However serum phosphate can fall
following acute correction of marked hyperthyroidism (hungry bones).
Serum PTH tends to be a bit high in hypothyroidism and a bit low in
hyperthyroidism, and renal tubular handing of phosphate probably changes
accordingly - however the effect on serum phosphate is small.
Apart from bones, phosphate metabolism in skeletal muscle is markedly
abnormal in hypothyroidism. Is serum calcium OK (ionized or
otherwise)
See Bill Fraser's paper from 1991 (Acta Endocrinologica 124:652-7).
Since you are probably interested in non-human lifeforms, see also
J. Am. Vet. Med. Assoc. 1991, Vol.198, No.1, pp.81-88 about hypothyroid
llamas
Aubrey Blumsohn
Directorate of Biochemical Medicine
Ninewells Hospital
Dundee
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