Mike,
It is still too early to tell but this is currently being studied more
globally; see recent article in JAMA (JAMA 2010; 303:1151-58)
Godfrey
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Hallworth Mike
(RLZ)
Sent: Thursday, June 10, 2010 4:48 AM
To: [log in to unmask]
Subject: Re: GFR
Hi Anders
I'm glad we amuse you, but it is worth noting that the introduction of
eGFR reporting in the UK has had a significant impact on getting faster
referrals to specialist renal care, with one report stating that the
number of patients referred late for specialist care fell from 38% to
25% following eGFR introduction (Bebb and Burden, BMJ 2007; 334: 1287).
This is supported by data from the UK Renal Registry. So there is
evidence that patients benefit, even though eGFR may not satisfy the
metrologists!
Mike
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Anders Kallner
Sent: 09 June 2010 17:19
To: [log in to unmask]
Subject: GFR
It amuses me to note that the UK (and US)colleagues still seem to
believe that S-Creatinine concentrations can be used to diagnose CKD in
spite of the large biological inter individual variation that Callum
Fraser (Dundee) nicely demonstrated in 80-ies. The variation is not
decreased by multiplying the measured S-Creatinine concentration by one
or other constant. On the contrary the gender and age variations
increase by the operation. You may still very well use the S-Creatinine
concentration to monitor disease and the mutilated value, erroneously
referred to as GFR, as well.
Anders Kallner
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