I don't there is a laboratorian on my side of the pond that would disagree with you; however, I don't think laboratorians drove the process; it was govt folks in the National Kidney Foundation and National Institute of Health.
Dr. Alter
-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Anders Kallner
Sent: Wednesday, June 09, 2010 12:19 PM
To: [log in to unmask]
Subject: GFR
It amuses me to note that the UK (and US)colleagues still seem to
believe that S-Creatinine concentrations can be used to diagnose CKD
in spite of the large biological inter individual variation that
Callum Fraser (Dundee) nicely demonstrated in 80-ies. The variation is
not decreased by multiplying the measured S-Creatinine concentration
by one or other constant. On the contrary the gender and age
variations increase by the operation. You may still very well use the
S-Creatinine concentration to monitor disease and the mutilated value,
erroneously referred to as GFR, as well.
Anders Kallner
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