Anders,
We were not amused when eGFR was imposed by dictat ignoring Calum
Fraser's work, the inadequacy of the study on which eGFR was based, the
lack of a CRM and no-one thought to suggest an enzymic assay instead of
the disparate methods still in use! But as a screening tool for chronic
kidney disease: maybe?
Now we await the use of creatinine as the only currently available
marker for Acute Kidney Injury: will we learn from past mistakes? We
have had discussions with the nephrologists nationally, so there may be
better understanding from them, which will be useful. We shall
see............
Ian
Dr Ian D Watson
Clinical Director, Clinical Laboratories
Consultant Biochemist & Toxicologist
Dept Clinical Biochemistry
University Hospital Aintree
Lower Lane
Liverpool
L9 7AL
Tel +44 151 529 3575
Fax +44 151 529 3310
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Anders Kallner
Sent: 09 June 2010 17:19
To: [log in to unmask]
Subject: GFR
It amuses me to note that the UK (and US)colleagues still seem to
believe that S-Creatinine concentrations can be used to diagnose CKD
in spite of the large biological inter individual variation that
Callum Fraser (Dundee) nicely demonstrated in 80-ies. The variation is
not decreased by multiplying the measured S-Creatinine concentration
by one or other constant. On the contrary the gender and age
variations increase by the operation. You may still very well use the
S-Creatinine concentration to monitor disease and the mutilated value,
erroneously referred to as GFR, as well.
Anders Kallner
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