In response to James Miller's question, we examined creatinine levels in a
study of steroid metabolite excretion in consecutive 3h collections over 24
in healthy adult male and female volunteers (Jerjes et al 2006 Ann Clin
Biochem 43, 287-294). We found no circadian rhythm. I too had heard from
somewhere that there is a rhythm, but haven't located a reference. It is
worth noting that relating a urinary analyte to creatinine does not really
overcome the variabliity of untimed collections unless that analyte also
shows no circadian rhythm. In the case of steroids, which show a
pronounced circadian rhythm, it would be of very limited use unless start
and finish times were standardised, although it must iron out some of the
variability due to variable water intake.
NF Taylor PhD FRCPath
Consultant Clinical Scientist
Director SAS Urinary Steroid Profiling Laboratory
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