It is possible that there is a small rhytm due to gluconeogenesis which
will only be picked up with an enzymatic rather Jaffe reaction
assessment.
JML
Dr John M. Land
Clinical Lead Biochemical Medicine
UCLH NHS Foundation Trust
Neurometabolic Unit Box 105
National Hospital
Queen Square
London WC1N 3BG
44-(0)20-7829-8768
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Norman Taylor
Sent: 28 March 2008 13:14
To: [log in to unmask]
Subject: creatinine circadian rhythm
In response to James Miller's question, we examined creatinine levels in
a
study of steroid metabolite excretion in consecutive 3h collections over
24
in healthy adult male and female volunteers (Jerjes et al 2006 Ann Clin
Biochem 43, 287-294). We found no circadian rhythm. I too had heard
from
somewhere that there is a rhythm, but haven't located a reference. It is
worth noting that relating a urinary analyte to creatinine does not
really
overcome the variabliity of untimed collections unless that analyte also
shows no circadian rhythm. In the case of steroids, which show a
pronounced circadian rhythm, it would be of very limited use unless
start
and finish times were standardised, although it must iron out some of
the
variability due to variable water intake.
NF Taylor PhD FRCPath
Consultant Clinical Scientist
Director SAS Urinary Steroid Profiling Laboratory
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