Wendy, If you want some expert and up to date advice on this please contact
Chris Packham at Enviroderm.
Wendy Jones
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Sent by: Subject: [OCC-HEALTH] Pregnancy risk assessment - aspirin-like substances
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IL.AC.UK
19/04/2007 17:05
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I have been asked to advise on a pregnancy risk assessment for someone in
our chemistry department. The work is based on samples of Aspirin like
compounds, specifically those found in treatments for ulcerative colitis
such as sulphasalazine, mesalazine and Balsalazide; and samples of Ferric
chloride. The work will last about 5 weeks, and the pregnancy is half way
through.
Having checked the BNF, aspirin is not restricted in pregnancy,
sulphasalazine and mesalazine are to be 'used with caution' and balsalazide
is to be avoided. The concentrations in the experiments will be low -
equivalent to the levels of aspirin -like compounds likely to be found on
the urine of someone taking therapeutic doses of drugs for inflammatory
bowel disease. On this basis my inclination is to let the work go ahead.
I would appreciate any comments from someone with greater chemical
expertise
than me if you think I'm missing something and should be saying no.
Incidentally they have also asked about using Mercuric Chloride in very
small quantities and I am going to be advising against this as it has known
reproductive effects in addition to its general high level of toxicity.
Regards
Wendy
Wendy Jones
Occupational Health Adviser
Loughborough University
01509 222851
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