Ann,
In my experience subjects who are zinc deficient do not have a low measured
ALP and my assumption has been that the added zinc in the reagent set is
more than enough to over-ride low serum levels (that's why it's added).
Of course low bone ALP (by electrophoresis) is very much found in
middle-aged osteoporotic subjects who have zinc deficiency.
Nick Miller
London
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Ann Read
Sent: 20 November 2006 00:25
To: [log in to unmask]
Subject: ALP and zinc deficiency
Hi everyone,
ALP has been a useful indicator of zinc deficiency. Can anyone tell me if
this is still the case when most ALP methods have added zinc which was not
the case in the past. I am not sure whether added zinc in vitro can
compensate for an enzyme which is zinc deplete -- I assume not, but I don't
know.
Ann
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