Taking the opportunity of a major change in laboratory analyser (Vitros 950
--> Roche Modular) we have swapped our main liver function test transaminase
from AST to ALT. With only a very small correlation to go on with our
previous method, we decided to adopt the manufacturer's suggested reference
ranges as our 'norm' (Females 5 - 31, Males 12 - 41 U/L). These are
identical or very close to those quoted by neighbouring laboratories.
However, following the change, we have noted a substantial number of mildly
elevated ALT resuts in adult patients with otherwise normal LFTs. (This was
not evident when AST was the measured transaminase). Are our ranges wrong?
Or is the ALT indicating a local population of patients with mild liver
damage ('retired, but drinks a lot')?. Any comments would be gratefully
received.
Brian Martin
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