Nian Huang wrote:
> Hi, all,
> I met some crystal structures with disordered active sites. Soaking
> common ligands can not make it become ordered. I am wondering what
> people generally do in such situation.
>
> Thanks,
>
> Nian Huang
>
>
Swear?!
This is quite common - the usual tricks may work - Sulphate ,
phosphate may bind there but it depends on your true substrate, and
often it takes a clever chemist to make a suitable substrate mimic.
Eleanor
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