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Nian Huang wrote: > Hi, all, > I met some crystal structures with disordered active sites. Soaking > common ligands can not make it become ordered. I am wondering what > people generally do in such situation. > > Thanks, > > Nian Huang > > Swear?! This is quite common - the usual tricks may work - Sulphate , phosphate may bind there but it depends on your true substrate, and often it takes a clever chemist to make a suitable substrate mimic. Eleanor