Derrr....................they assume that is the case already! Comes as a shock when they find outotherwise
-----Original Message-----
From: Jonathan Kay [mailto:[log in to unmask]]
Sent: 15 October 2015 11:01
To: David James; [log in to unmask]
Cc: Jonathan Kay
Subject: Re: ALT reference intervals
It's an excellent question.
As would be asking clinicians and patients if they'd like results to be much more transferable. It might be worth establishing that one before asking the laboratories...
Jonathan
On 15 Oct 2015, at 10:50, David James <[log in to unmask]> wrote:
> "..........................but what else can be done when laboratories don't use standardised methods?"
>
> So, a question -
>
> If someone (and let's not get hung up on who) pronounced for example -
>
> "In the UK all ALT measurements must be done by IFCC method with PP" (assuming that all manufacturers had that method available for their analysers)
>
> How many labs would decide they knew better? It's a serious question
>
> DJ
>
> -----Original Message-----
> From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Jonathan Kay
> Sent: 15 October 2015 10:27
> To: [log in to unmask]
> Subject: Re: ALT reference intervals
>
> IMHO it's generally better not to bring "healthy" or "normal" into this. The question is whether you can distinguish the two populations of interest. The unaffected population may not be healthy.
>
> Recommended reading, as ever: Galen and Gambino, and the NORDKEM reports from the mid 80s.
>
> And "Yes", those mentions of twice the upper limit are an attempt to get round inter-laboratory variation. A third-rate attempt, but what else can be done when laboratories don't use standardised methods?
>
> Jonathan
>
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