Prolactin is measured at Preston on a Chiron Centaur analyser. The recent UK NEQAS Dist 226 showed that this method has little, if any, reponse to macroprolactin.
How clinically significant is macroprolactin ? Is it better to have an assay which measures macroprolactin but have a strategy for determining its presence in hyperprolactinaemia or is it better to have an assay which does not detect it ?
The former will demand extra tests to screen high prolactins whilst the latter might miss clinically significant macroprolactinaemia.
I would appreciate contributions to this question.
Thanks
Dr W Collins
Royal preston Hospital
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