Reply-To: | | [log in to unmask][log in to unmask], 2 Apr 1999 16:25:17 -0500 (EST)681_US-ASCII Was a CSF specimen obtained and was electrophoresis performed in the CSF specimen? What neurological symptoms did the patient have? Tetraclonality cannot be defined by the number of narrow bands. There have to be 4 different clones of plasma cells, each one secreting a different immunoglobulin molecule (even if of the same class and type). Are these 4 bands of IgG kappa of the same subclass? Multiple narrow bands in electrophoresis can be due to oligoclonal proteins, i.e., a more restricted immunoglobulin distribution (e.g., only IgG1). Also, there can be polymerization (or aggregation) of an immunoglobulin giving multiple bands or [...]51_2Apr199916:25:17-0500(EST)[log in to unmask] |