To all,
The use of the best method for creatinine clearance is an interesting
debate. The use of the Cockcroft and Gault formula to devise digoxin
doses etc, has long been used by those involved in Therapeutic Drug
Monitoring, and persuading clinicians to use this method is difficult.
We are now working with oncologists who would like to use the EDTA
method, so I am interested in Dr Falconer-Smith's experience. Are the
oncolgists happy to use C & G (its certainly cheaper) when devising the
carboplatin dose? After all the dose is fairly crude anyway.
And what about say a 4 hour creatinine clearance? We have been using a
2 hour clearance in one study and is not really satisfactory.
Graham Mould
Guildford Clinical Pharmacology Unit
Royal Surrey County Hospital
guildford, Surrey
Tel 01483 406886
Fax 01483 455375
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
|