Urinary lactic acid measurements are useful in the investigation of metabolic
disorders. Lactic acid is usually quantified by GC-MS techniques as part of a
urinary organic acid profile. We recommend urinary organic acid profiling (and
lactic acid quantification) in infants with biotinidase deficiency detected in
neonatal screening. Urinary lactate levels can get quite high in this disorder
due to a functional deficiency of pyruvate carboxylase. The same holds true for
holocarboxylase synthetase deficiency ( a much rarer form of holocarboxylase
deficiency). Both conditions are due to defects in biotin metabolism. Here is a
reference for laboratory measurement:
L. Sweetman. Organic acid analysis. In: Hommes FA, ed., Techniques in
diagnostic human biochemical genetics: A laboratory manual. New York:
Wiley-Hiss, 1991: 143-176.
Timothy Foley
New England Newborn Screening Program
UMASS Medical Center
Boston, MA
____________________Reply Separator____________________
Subject: Lactate in urine
Author: [log in to unmask]
Date: 7/29/98 4:16 PM
Dear colleagues,
I was recently asked to comment on the usefulness of lacatate analysis
in urine.
Lactate in blood plasma, cerebrospinal fluid, pleural and ascitic
samples are well-known to me. I have checked several textbooks for
lactate estimation in urine - without success.
Your input will be appreciated.
Dr. med. Michael Steiner
University of Rostock
Institute of Clinical Chemistry & Pathobiochemistry
Ernst-Heydemann-Str. 6
18057 Rostock
Germany
fax: +49/381/494-7672
email: [log in to unmask]
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