Hello,
if you investigate a population spanning a large age range, you will
always have to compromise. If your sample were large (as in really,
really large), creating your own template would be an option, but you
already implied that this is not the case. If you therefore do not want
to go with the standard template (which I wouldn't either) you could
look into template creation toolboxes. As it so happens I know of one
that would span the age range you are interested in and is able to
create a template matched 1:1 to your input population. You can find
more details about the CerebroMatic at
https://www.medizin.uni-tuebingen.de/kinder/en/research/neuroimaging/software/
Note that while you look into this, you might want to download the
DARTEL dataset as well, as that is usually the next question ;)
Cheers
Marko
Jale Özyurt schrieb:
> Dear All,
>
> I am planning an MR brain imaging study to compare patients with brain tumors of the sellar/parasellar region to matched healthy controls. As it is a rare tumor, we will include a large age range (14-50 years old). In 14 to 20 years old participants in particular there may be still considerable changes in brain anatomy, size, tissue.
>
> For this reason, I just wonder whether it is justified to use the standard adult template for normalization of all participants?
>
> I would very much appreciate any suggestions on this issue.
>
> Best,
>
> Jale
>
--
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Prof. Dr. med. Marko Wilke
Facharzt für Kinder- und Jugendmedizin
Leiter, Experimentelle Pädiatrische Neurobildgebung
Oberarzt der Abteilung Neuropädiatrie
Universitäts-Kinderklinik
Marko Wilke, MD, PhD
Pediatrician
Head, Experimental Pediatric Neuroimaging
Consultant in Pediatric Neurology
University Children's Hospital
Hoppe-Seyler-Str. 1
D - 72076 Tübingen, Germany
Tel. +49 7071 29-83416
Fax +49 7071 29-5473
[log in to unmask]
http://www.medizin.uni-tuebingen.de/kinder/epn/
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