Hello,
w.r.t. your first question, I am biased in so far as I would probably
tend to suggest the ones I have developed (see the URL in my footer for
more information).
W.r.t. your second question, that indeed is an issue. However, my
position on this is that, yes, you get MNI coordinates when using an
adult template, but they are wrong as the normalization is biased. If
you use (any!) custom templates, you may not get MNI coordinates
directly comparable to those obtained in other studies, but at least
they should be less biased. And, localization: I usually get away with
simply looking at where the activation occurred and to which anatomical
structure in the template they can be ascribed.
Cheers
Marko
Ariadna Albajara Sáenz schrieb:
> Dear Marko,
> Thank you for your answer. Would you recommend any pediatric template in
> particular? What about the localisation of the activation then? Since I
> guess MNI coordinates would not be valid anymore for localisation.
>
> Thank you in advance,
> *Ariadna Albajara Sáenz*
> [log in to unmask] <mailto:[log in to unmask]>_
> UR2NF - Neuropsychology and Functional Imaging Research Group
> CRCN - Center for Research in Cognition and Neurosciences
> http://crcn.ulb.ac.be/
> *
> *
> UNIVERSITÉ LIBRE DE BRUXELLES, Avenue F. Roosevelt 50, CP 151, 1050
> Brussels (Belgium).
> Office: DB10-237
>
>
> El vie., 5 abr. 2019 a las 9:22, Marko Wilke
> (<[log in to unmask]
> <mailto:[log in to unmask]>>) escribió:
>
> Hello Ariadna,
>
> as always, the answer is "it depends". The issue when comparing
> children vs. adults can indeed be expected to be more pronounced as
> you have a systematic bias between groups. If you compare children
> with children using an adult template, you must expect to have a
> systematic bias for both groups. You could argue that this therefore
> does not invalidate your comparison but it will be a bias
> nonetheless. It is up to you if you want to go there. My suggestion
> (not suprprisingly) would be to use a pediatric template as 8-12
> year-old brains are really rather different from adults.
>
> Cheers
> Marko
>
> > Dear SPMexperts,
> >
> > I am comparing groups of children within the same age range
> (patients versus
> > controls) aged 8 to 12 and I was wondering if in this case it is
> necessary to
> > use a pediatric template . I have read that it is specially
> important if we
> > compare children to adults, but it is not my case. Is it
> necessary if we
> > compare children with the same age?
> >
> > Thank you in advance,
> >
> > Ariadna
>
>
> --
> ____________________________________________________
> Prof. Dr. med. Marko Wilke
> Facharzt für Kinder- und Jugendmedizin
> Leiter, Experimentelle Pädiatrische Neurobildgebung
> Oberarzt der Abteilung Neuropädiatrie
> Universitäts-Kinderklinik
>
> Marko Wilke, MD, PhD
> Pediatrician
> Head, Experimental Pediatric Neuroimaging
> Consultant in Pediatric Neurology
> University Children's Hospital
>
> Hoppe-Seyler-Str. 1
> D - 72076 Tübingen, Germany
> Tel. +49 7071 29-83416
> Fax +49 7071 29-5473
> [log in to unmask]
> <mailto:[log in to unmask]>
>
> http://www.medizin.uni-tuebingen.de/kinder/epn/
> ____________________________________________________
>
>
>
--
____________________________________________________
Prof. Dr. med. Marko Wilke
Facharzt für Kinder- und Jugendmedizin
Leiter, Experimentelle Pädiatrische Neurobildgebung
Oberarzt der Abteilung Neuropädiatrie
Universitäts-Kinderklinik
Marko Wilke, MD, PhD
Pediatrician
Head, Experimental Pediatric Neuroimaging
Consultant in Pediatric Neurology
University Children's Hospital
Hoppe-Seyler-Str. 1
D - 72076 Tübingen, Germany
Tel. +49 7071 29-83416
Fax +49 7071 29-5473
[log in to unmask]
http://www.medizin.uni-tuebingen.de/kinder/epn/
____________________________________________________
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