Hi Chris - a timely post, since there was an industry sponsored workshop hosted by Abbott at Focus yesterday on this topic. It was well attended and provoked lively and thoughtful discussion, and a report will appear in ACB News soon.
Also, the ACB Scientific Committee will be publishing a position paper on biotin interference in the near future, and you might wish to contact Chris Chaloner, the SC Chair, for more details of that.
Looking forward to further mailbase contributions on the issue!
Mike Hallworth
Focus 2018 Chair
Sent from my iPad
> On 8 Jun 2018, at 16:18, Chris Boot <[log in to unmask]> wrote:
>
> Dear Colleagues,
>
> The number of cases of biotin interference in immunoassays using biotinylated antibodies being reported in the literature seems to be increasing. We are also receiving safety alerts from a number of immunoassay manufacturers on the subject. I have seen a couple of cases locally, where paediatric patients on mega-doses of biotin prescribed for metabolic/mitochondrial disorders have developed spurious biochemical hyperthyroidism (gross negative interference in TSH and positive interference in free thyroid hormones). The most alarming reported case I have seen is an alert the FDA apparently received regarding a patient who had a false negative troponin result, put down to biotin interference (the patient died):
>
> https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm586641.htm
>
> Have any of you developed a policy as to how to deal with this problem? I think user education is the key here (as suggested in the above FDA communication), particularly clinicians who prescribe high doses of biotin (although there are individuals out there taking quite high doses of biotin for its purported health/beauty benefits).
>
> Happy to summarise the approaches being taken if you would prefer to reply to me directly.
>
> Kind Regards,
>
> Chris
>
> [log in to unmask]
>
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