To develop knowledge, it is more important to focus on what research question have not been asked.
"The Importance of Potential Studies That Have Not Existed and Registration of Observational Data Sets"
John P. A. Ioannidis, MD, DSc http://jamanetwork.com/journals/jama/article-abstract/1309181
For example, "apart from pharmacovigilance, vaccinevigilance is needed to save money and harm"
http://www.bmj.com/content/357/bmj.j2841/rr-0
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