That's true, Mohammad.
Chesinta Voma, PhD
University of Louisville
School of Medicine
Department of Pathology & Laboratory Medicine
Clinical Chemistry Fellowship
Psalms 7:10. "My defense is of God who saves the upright in heart".
--------------------------------------------
On Fri, 4/8/16, Mohammad Al-Jubouri <[log in to unmask]> wrote:
Subject: Re: Elevated Trop T necrotic pancreatis
To: [log in to unmask]
Date: Friday, April 8, 2016, 10:15 AM
#yiv1046637568
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Also the heart could be involved
in rhabdomyolysis.
From: Clinical biochemistry discussion
list [mailto:[log in to unmask]]
On Behalf Of Mohammad Al-Jubouri
Sent: 08 April 2016 12:43
To: [log in to unmask]
Subject: Re: Elevated Trop T necrotic
pancreatis
Hi Nicola,
The raised TnT is from skeletal
muscle due to rhabdomyolysis rather than the heart.
Regenerated skeletal muscle do produce TnT.
Regards
Mohammad
From: Clinical biochemistry discussion
list
[mailto:[log in to unmask]]
On Behalf Of Pullan Nicola (ROYAL UNITED HOSPITALS
BATH NHS FOUNDATION TRUST)
Sent: 08 April 2016 12:15
To: [log in to unmask]
Subject: Elevated Trop T necrotic
pancreatis
Dear Mailbase,
Can anyone help with the
following?
ITU patient admitted with acute
pancreatitis 16/3/16 due to ?alcohol/drugs, developed
rhabdomyolysis with a peak CK (25/3/16) of 127k,
haemofiltered, latest
CK (5/4/16) is normal.
Troponin T (hs Cobas method) first
measured 30/3/16 = 1317 ng/L, further increased over next
few days to peak at 5225 ng/L on 6/4/16, latest result is
5098
ng/L on 7/4/16.
No abnormality of heart detected
by scans etc.
The reason for the troponin
request in the first place was non-specific – just what
ITU tend to do in septic patients!
He has a necrotic head of
pancreas.
Question:
Could the necrotic pancreas be
releasing troponin or something that’s cross-reacting or
causing interference in the Troponin T assay?
I would be grateful of any
suggestions as the what could be going on here.
Many thanks,
Nicola
Nicola
Pullan
Principal Clinical Biochemist
Royal
United Hospitals Bath NHS Foundation Trust
Combe Park, Bath, BA1 3NG
Dir Line: 01225 824711
Visit our website at: www.ruh.nhs.uk/pathology
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