Hi John,
So this newborn has non-PTH mediated hypercalcaemia that can be due to:
1. Maternal causes, probable.
2. Idiopathic hypercalcaemia of infancy, quite possible.
3. William's syndrome, usually has other facial, cardiovascular and neurological stigmata, so probably not this.
Could you measure 1,25 dihydroxy vitamin D?
Best wishes
Mohammad
Dr. M A Al-Jubouri, MB ChB, MSc, EurClinChem, FRCP Edin, FRCPath
Consultant Chemical Pathologist
--------------------------------------------
On Fri, 21/8/15, OConnor John (ROYAL DEVON AND EXETER NHS FOUNDATION TRUST) <[log in to unmask]> wrote:
Subject: Hypercalcaemia in a 14 day old infant
To: [log in to unmask]
Date: Friday, 21 August, 2015, 10:28
Dear Collective
We have a 14 day old
infant with a Corrected Calcium of 3.14 mmol/L rising since
first measurement at Day 8 which was 2.98 mmol/L
PO4= 1.78 mmol/L
PTH = 0.4 pmol/L
Vit D = 84 nmol/L
Creat < 18 mmol/L (The
joys of having to put up with a Jaffe method) so I cant work
out the Ca/Cre ratio to exclude FHH
The infant is being breast
fed and was term baby
Looks normal, one doc
thought about Williams syndrome
There is a suspicion that
mum may have been aggressively Vit D supplementing during
pregnancy
I do not have her levels
yet but am chasing this
Does anyone have any Vit D
ranges for neonatal going into infant age related
ranges
84 feels high to me?
BW John
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