Yes, Philip, I do red cell NAD/NADP ratios as a marker of cellular B3 status.
In the situation you describe most clinicians will give B3 (= shoot first) and then look for B3 deficiency afterwards.
In case you want to pursue this I will send you details off-Mailbase tomorrow.
Nick Miller
London
-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Phillip Monaghan
Sent: 03 January 2013 14:21
To: [log in to unmask]
Subject: Testing for Pellagra
Dear colleagues,
One of our clinicians would like to investigate a possible diagnosis of pellagra in a patient with suspected carcinoid syndrome. Are there any labs that offer testing that may help confirm such a diagnosis, for example, plasma tryptophan or niacin measurement, RBC NAD/NADP, or urinary N-methyl nicotinamide or 2-pyridone? I have no hits on AssayFinder. I don’t have much experience in this area, could they give nicotinamide and see if symptoms resolve?
Any guidance appreciated.
Kind regards,
Phil
___________________________________
Dr Phillip J Monaghan BSc MSc PhD
Senior Clinical Scientist
Department of Clinical Biochemistry
The Christie Hospital NHS Foundation Trust Wilmslow Road Withington Manchester
M20 4BX
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This is an open discussion list for the academic and clinical community working in clinical biochemistry.
Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content.
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