As requested by Jonathan

Reference List

	1. 	Bradburn M, Goodacre SW, Fitzgerald P et al.
Interhospital variation in the RATPAC Trial (Randomised Assessment of
Treatment using Panel Assay of Cardiac markers). Emerg.Med.J.
2012;29:233-8.
	2. 	Goodacre SW, Bradburn M, Mohamed A et al. Evaluation of
Global Registry of Acute Cardiac Events and Thrombolysis in Myocardial
Infarction scores in patients with suspected acute coronary syndrome.
Am.J.Emerg.Med. 2012;30:37-44.
	3. 	Reichlin T, Schindler C, Drexler B et al. One-Hour
Rule-out and Rule-in of Acute Myocardial Infarction Using
High-Sensitivity Cardiac Troponin T. Arch.Intern.Med. 2012;172:1211-8.
	4. 	Collinson P, Goodacre S, Gaze D et al. Very early
diagnosis of chest pain by point-of-care testing: comparison of the
diagnostic efficiency of a panel of cardiac biomarkers compared with
troponin measurement alone in the RATPAC trial. Heart 2011.
	5. 	Goodacre S, Bradburn M, Fitzgerald P et al. The RATPAC
(Randomised Assessment of Treatment using Panel Assay of Cardiac
markers) trial: a randomised controlled trial of point-of-care cardiac
markers in the emergency department. Health Technol.Assess.
2011;15:iii-102.
	6. 	Goodacre SW, Bradburn M, Cross E et al. The Randomised
Assessment of Treatment using Panel Assay of Cardiac Markers (RATPAC)
trial: a randomised controlled trial of point-of-care cardiac markers in
the emergency department. Heart 2011;97:190-6.
	7. 	Than M, Cullen L, Reid CM et al. A 2-h diagnostic
protocol to assess patients with chest pain symptoms in the Asia-Pacific
region (ASPECT): a prospective observational validation study. Lancet
2011;377:1077-84.
	8. 	Ryan RJ, Lindsell CJ, Hollander JE et al. A multicenter
randomized controlled trial comparing central laboratory and
point-of-care cardiac marker testing strategies: the Disposition
Impacted by Serial Point of Care Markers in Acute Coronary Syndromes
(DISPO-ACS) trial. Ann.Emerg.Med. 2009;53:321-8.
	9. 	Hamilton AJ, Swales LA, Neill J et al. Risk
stratification of chest pain patients in the emergency department by a
nurse utilizing a point of care protocol. Eur.J.Emerg.Med. 2008;15:9-15.
	10. 	Rathore S, Knowles P, Mann AP et al. Is it safe to
discharge patients from accident and emergency using a rapid point of
care Triple Cardiac Marker test to rule out acute coronary syndrome in
low to intermediate risk patients presenting with chest pain?
Eur.J.Intern.Med. 2008;19:537-40.
	11. 	Renaud B, Maison P, Ngako A et al. Impact of
point-of-care testing in the emergency department evaluation and
treatment of patients with suspected acute coronary syndromes.
Acad.Emerg.Med. 2008;15:216-24.
	12. 	Straface AL, Myers JH, Kirchick HJ et al. A rapid
point-of-care cardiac marker testing strategy facilitates the rapid
diagnosis and management of chest pain patients in the emergency
department. Am.J.Clin Pathol. 2008;129:788-95.
	13. 	Apple FS, Chung AY, Kogut ME et al. Decreased patient
charges following implementation of point-of-care cardiac troponin
monitoring in acute coronary syndrome patients in a community hospital
cardiology unit. Clin Chim.Acta 2006;370:191-5.


-----Original Message-----
From: Jonathan Kay [mailto:[log in to unmask]] 
Sent: 16 October 2012 16:59
To: Paul Collinson
Cc: Jonathan Kay
Subject: Re: Troponin testing in A&E / acute admissions units

AMENDED (!)

I think it would help everyone if you felt able to post the
references...

Best wishes

Jonathan

On 16 Oct 2012, at 16:44, Paul Collinson wrote:

> Apart from 1 Randomised controlled trial(published in Heart and winner
> of the Evidence based Medicine award of EFCC) 4 other studies and one
> observational study published in the Lancet
> 
> So not much then......
> 
> -----Original Message-----
> From: Clinical biochemistry discussion list
> [mailto:[log in to unmask]] On Behalf Of Webster Craig
> Sent: 12 October 2012 10:16
> To: [log in to unmask]
> Subject: Re: Troponin testing in A&E / acute admissions units
> 
> I kind of gave a talk on this area yesterday at the Society of Acute
> medicine conference in Manchester
> 
> I'm no expert but used
> 
> American Journal of emergency medicine vol 30 issue 8 1639-1649
October
> 2012
> 
> As a basis for my talk
> 
> From my reading there is very little hard evidence to support their
use
> at the moment
> 
> 
> Best wishes
> Craig
> 
> 
> Sent from my iPhone
> 
> On 12 Oct 2012, at 09:57, "Jordaan Marieke"
>
<[log in to unmask]<mailto:[log in to unmask]>
>> wrote:
> 
> According to company representatives there are several A&E /Acute
> Admissions departments where point of care testing of troponin is in
use
> or being introduced, and not only after 10 or 12 hours but on
admission
> and a few hours later, depending on local protocols.
> 
> On the other hand there is a desire / pressure to move to ever
> increasingly sensitive methods in the laboratory to facilitate earlier
> diagnosis and identification of the most appropriate care pathway.
> 
> How do other departments reconcile the two approaches, and
particularly
> where both types of testing are being used for the same patients?
> 
> 
> Regards
> 
> Marieke
> 

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