Although it is only an experimental animal model but might be relevant for this discussion:
Metabolism. 1979 Feb;28(2):97-9.Effect of glycerol on triglyceride metabolism in the rat.
Abe R, MacDonald I, Maruhama Y, Goto Y.
Abstract
Lipid metabolic studies were carried out on the male Wistar rats fed on glycerol-rich diet in order to elucidate the mechanism of glycerol-induced hypertriglyceridemia. No difference was found between the glycerol fed rats and the control rats in the rate of triglyceride secretion from the liver measured by the Triton WR-1339 method as well as in the rate of incorporation of labeled glycerol into liver triglyceride. The facts that the half-life of the intravenously injected Intralipid in the blood was significantly delayed in the glycerol fed rats and that the lipoprotein lipase activity released from epididymal adipose tissue of the glycerol fed rats was markedly decreased to 19% of that of the control rats seem to account for the serum triglyceride elevation induced by the glycerol feeding.
Regards, Rita
Prof. Andrea Rita Horvath, MD, PhD, EurClinChem, FRCPath, FRCPA
Past President of the European Federation of Clinical Chemistry and Laboratory Medicine
Clinical Director, SEALS North, Department of Clinical Chemistry
Level 4, Campus Centre, Prince of Wales Hospital
Barker Street, Randwick, NSW 2031, Sydney, Australia
Tel: (+612)-9382 9078
Fax: (+612)-9382 9099
Mobile No: (+61)-404 027 843
-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Jonathan Kay
Sent: Friday, 20 January 2012 10:20 AM
To: [log in to unmask]
Subject: Re: Potential triglyceride interference
Is the interference mole per mole in that assay?
I don't think it could happen after ingestion: the gut and liver would metabolise it.
But perhaps it could happen with topical contamination, as with the widely-observed contamination of PoCT glucose sticks by drinks containing glucose.
Have you got the original specimen?
Jonathan
On 19 Jan 2012, at 22:57, David Wright wrote:
> Roche Trig GPO PAP Cat No 11876023 216
>
> Elderly lady, lipid profile previously normal Oct & Nov 11, presents with grossly elevated triglyceride (92.1), otherwise normal profile.
> Serum without evidence of chylomicrons etc. Reaction trace on diluted sample normal. Indices normal (slight haemolysis 136).
> Repeated sample 2 days later, normal (1.55)
>
> Diagnosis - cough
>
> Method (Roche Modular P) indicates glycerol may interfere. Cough meds often contain glycerol. Coincidence? Can anyone confirm such a dramatic effect before I go down to the chemist!
>
> David Wright
> Biochemistry Dept
> Antrim Laboratory
>
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