Dear Dr. Azad
Thank you for the information and study. To me, based on my experience,
these type of comparisons are vitally critical if a facility is to
introduce additional bilirubin measurement devices outside the main
laboratory method.
I will leave the argument to others if outside the main lab Bilirubin
methods should or should not be introduced. I tend to be a realist in
terms of accepting that they will be! Therefore knowing the differences
upfront and communicating between the lab and the neonatologists will
help clarify decisions when interpreting total bili, age of the patient
and nomogram.
Thank you
Joe
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Rafaq Azad
Sent: Thursday, April 07, 2011 11:32 AM
To: [log in to unmask]
Subject: Re: Blood gas analyzers & bilirubin
Hi,
A paired sample comparison for 30 neonatal samples in our hospital
indicated a positive bias on the Roche omni S when compared with lab
method (vanadate oxidase), the results being up to 20 umol/L higher in
some cases. The difference did not appear to be concentration related,
probably highlighting a calibration issue?
(Page 250 of the abstract pages).
Raf.
Rafaq Azad
Principal Clinical Biochemist / Scientific Coordinator Born in Bradford
Department of Clinical Biochemistry Bradford Royal Infirmary Duckworth
Lane Bradford
BD9 6RJ
Tel: 01274 382683
E-mail: [log in to unmask]
http://www.borninbradford.nhs.uk/
>>> Jonathan Kay <[log in to unmask]> 02/04/2011 09:03 >>>
PubMed
http://www.ncbi.nlm.nih.gov/pubmed?term=comparison%20%22blood%20gas%22%2
0bilrubin
gives 14 hits
Google:
http://www.google.co.uk/search?client=safari&rls=en&q=comparison+%22bloo
d+gas%22+bilrubin
gives 220,000 hits
Would someone like to do a Systematic Review? One for the Scientific
Committee?
Jonathan
On 2 Apr 2011, at 08:52, Jonathan Kay wrote:
> Joe has asked the key question. If the methods give the same answer I
wouldn't worry about the specimen type being whole blood or skin
puncture fluid rather than serum.
>
> There is some previous discussion in the mailgroup:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?A2=ind02&L=ACB-CLIN-CHEM-G
> EN&P=R346255&1=ACB-CLIN-CHEM-GEN&9=A&J=on&d=No+Match%3BMatch%3BMatches
> &z=4
>
> Can anyone add relevant publications, device assessments or EQA data?
>
> The NICE guidance is at:
> http://guidance.nice.org.uk/CG98
>
> Jonathan
>
>
>
>
> On 1 Apr 2011, at 17:36, Indovina, Joe [OCDUS] wrote:
>
>> Dear Funmi
>>
>> Your post is intriguing. To me the bigger question is how well does
>> the bilirubin measurement form the Blood Gas analyzer correlate with
>> the clinical laboratory method. If the correlation is different and
>> not clearly defined, confusion in interpretation will be the outcome.
>> The differences may impact classification with the nomogram
>>
>> Joe I
>>
>>
>>
>> From: Clinical biochemistry discussion list
>> [mailto:[log in to unmask]] On Behalf Of Akinlade Funmi
>> (RF4) BHR Hospitals
>> Sent: Friday, April 01, 2011 12:36 PM
>> To: [log in to unmask]
>> Subject: Blood gas analyzers & bilirubin
>>
>> Hello all,
>> we recently introduced bilirubin on our blood gas
analyzer in NICU. At the moment they have a Pfaff Bilimeter 3 which
they've been using on the ward. The recently issued nice guidelines on
Neonatal Jaundice mention the use of serum bilirubin to diagnose and
follow up babies with jaundice. Does this then rule out the use of blood
gas analyzers to measure bilirubin in these babies?
>>
>> Also if your Hospital uses blood gas analyzers to measure bilirubin
how is it used on the ward?
>>
>> Kind regards,
>>
>> Funmi Akinlade
>> Barking, Havering and Redbridge University Hospitals NHS Trust,
>> Queen's Hospital, Romford.
>>
>> Barking, Havering & Redbridge University Hospitals NHS Trust: Most
>> Innovative Trust in London 2009
>>
>>
>
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