Hi Connie
This might not serve your purpose, but re your 2nd point, the original 6 month data on GI complications with celecoxib vs diclofenac or ibuprofen as represented in the CLASS RCT (Silverstein FE, et al. JAMA 2000;284:1247-1255) was very different from the up to 12 month data as subsequently described by Juni (Jüni P, et al. BMJ 2002; 324:1287-1288). There were protests, but the post hoc FDA analysis was scathing re the original analysis.
Bw
Neal
-----Original Message-----
From: Evidence based health (EBH) [mailto:[log in to unmask]] On Behalf Of Paul Glasziou
Sent: 08 March 2010 17:37
To: [log in to unmask]
Subject: Re: do small studies allow for big claims -- need a reference to this
Dear Connie
That's tricky as it seems to be three questions:
1. Are small studies enough (predicting the results of large studies)?
2. Do short term outcomes predict long term outcomes?
3. Are results from one setting generalisability across other settings
and patients?
Each of those is a major topic, but a generic start might be John
Ioannidis essay "Why most published research findings are false." PLoS
Med. 2005 Aug;2(8):e124. Epub 2005 Aug 30.
and its reference 36.
Best wishes
Paul Glasziou
Connie Schardt wrote:
> I've got a question from one of our EBM instructors:
>
> He's looking for an article/commentary that concludes that one small study
> in a specific population for a short amount of time is not adequate for
> making claims that everybody will see these effects over long periods of
> time.
>
> Anyone have a reference for this?
>
> Thanks,
>
>
> Connie
>
> Connie Schardt
> Medical Center Library
> Duke University
>
>
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