Hi there.
Clostridial Alpha toxins (phospholipase Cs that cause gas gangrene)
bind 2-3x Zinc in the catalytic site, and 2-3 Ca in the membrane
binding domain.
See 1ca1, 1olp, 1qmd and others.
Dave
2008/6/13 Neeraj Kapoor <[log in to unmask]>:
> Hi all,
> I recently came across a question about an interesting idea. Does
> anyone know of an example of a protein binding to both Zn2+ and Ca2+ at the
> same time? Are there any known well studied precedents at all if any. Any
> help of insights would be very valuable.
>
> thanks,
> Neeraj
>
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David C. Briggs PhD
Father & Crystallographer
http://www.dbriggs.talktalk.net
AIM ID: dbassophile
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