Concanavalin A can be made to bind Zn and Ca. Its binding site has room for
one transition metal and one alkaline earth metal.
http://www.jbc.org/cgi/content/abstract/271/27/16144
Highly recommended reading material on one of the classical protein targets
Sumner's Nobel Prize lecture is here
http://nobelprize.org/nobel_prizes/chemistry/laureates/1946/sumner-lecture.p
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Artem
-----Original Message-----
From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of Neeraj
Kapoor
Sent: Thursday, June 12, 2008 11:15 PM
To: [log in to unmask]
Subject: [ccp4bb] Protein binding to Zn and Ca
Hi all,
I recently came across a question about an interesting idea.
Does anyone know of an example of a protein binding to both Zn2+ and
Ca2+ at the same time? Are there any known well studied precedents at
all if any. Any help of insights would be very valuable.
thanks,
Neeraj
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