But a causal relationship between homocysteine and CHD was assumed and clinical trials of reducing homocysteine by vitamin therapy (e.g. NOR-VIT) have not shown any benefit of homocysteine reduction. So, evidence of a possible causal relationship must be treated with extreme caution...
*************************************************************************************
Prof. Tim Reynolds,
Queen's Hospital,
Belvedere Rd,
Burton-on-Trent,
Staffordshire,
DE13 0RB
work tel: 01283 511511 ext. 4035
work fax: 01283 593064
work email: [log in to unmask]
home email: [log in to unmask]
**************************************************************************************
IMPORTANT: This email is intended for the use of the individual addressee(s)named above and may contain information that is confidential privileged or unsuitable for overly sensitive persons with low self-esteem, no sense of humour or irrational religious beliefs [if you want to believe in fairy stories and hug pixies that's up to you]. If you are not the intended recipient, any dissemination, distribution or copying of this email is not authorized (either explicitly or implicitly) and constitutes an irritating social faux pas. Unless the word absquatulation has been used in its correct context somewhere other than in this warning, it does not have any legal or grammatical use and may be ignored. No animals were harmed in the transmission of this email, though the kelpie next door is living on borrowed time, let me tell you. Those of you with an overwhelming fear of the unknown will be gratified to learn there is no hidden message revealed by reading this backwards, so just ignore that Alert Notice from Macroshaft. However, by pouring a complete circle of salt around yourself and your computer you can ensure that no harm befalls you and your pets. If you have received this eMail in error, please add some nutmeg and egg whites, whisk, and place in a warm oven for 40 minutes.
-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Joseph WATINE
Sent: 25 May 2007 12:16
To: [log in to unmask]
Subject: Re: Lp(a) weekend question
as far as I am aware, 3 systematic reviews have been published on the
subject; their conclusions are:
1) although C-reactive protein, lipoprotein(a), fibrinogen, and homocysteine
are associated with vascular disease risk, their optimal use in routine
screening and risk stratification remains to be determined [Hackam et al.
JAMA 2003; 290:932-40].
2) prospective studies demonstrate a clear association between Lp(a) and
CHD, but further studies are needed to determine the extent to which this is
causal [Danesh et al. Circulation 2000; 102:1082-5].
3) these findings provide evidence in support of a causal role for Lp(a) in
the development of atherosclerosis. Measurement of Lp(a) may be useful to
guide management of individuals with a family history of IHD or with
existing disease. The separation in values between cases and controls is
not, however, sufficient to allow the use of Lp(a) as a screening test in
the general population [Craig et al. Clin Chem 1998; 44:2301-6.]
Dr Joseph Watine, PH, AIHP, PharmD, AAHU, EurClinChem Laboratoire de Biologie Polyvalente Centre Hospitalier Général 12027 Rodez Cedex 9 France
>From: Andrea Horvath <[log in to unmask]>
>Reply-To: Andrea Horvath <[log in to unmask]>
>To: [log in to unmask]
>Subject: Re: Lp(a) weekend question
>Date: Fri, 25 May 2007 12:26:47 +0200
>
>See some selected (but old!) references on the topic
>Lippi G, Guidi G: Q J Med 2000, 93.75-84
>Craig WY et al: Clinical Chemistry 44:11: 2301-2306 (1998) - a
>meta-analysis
>Rifai N et al: Clinical Chemistry 50:8: 1364-1371 (2004)
>
>These were on my files, but the literature is vast on the topic - see
>Medline!
>One point is that LP(a) has a so-called cringle structure (apparently the
>cringle domains were discovered by a Hungarain!) that makes this molecule
>similar to plasminogen. Thus it interferes, amongst many other things, with
>plasminogen-plasmin activity. This explains its thrombogenic effect (OK,
>not the atherogenic, but I believe these things through the problems of
>plaqua rupture are inter-ralated). A more precise description of the
>mechanism is in the above papers and reviews.
>
>BW: Rita Horvath (Hungary)
>
>At 10:02 2007.05.25. +0100, Paul Collinson wrote:
>>I do not think anyone knows although it is rumoured to contribute to
>>plaque repair
>>
>>P. O. Collinson
>>
>>
>>-----Original Message-----
>>From: Clinical biochemistry discussion list
>>[mailto:[log in to unmask]] On Behalf Of Mohmed Ashmaig
>>Sent: 25 May 2007 05:39
>>To: [log in to unmask]
>>Subject: Lp(a) weekend question
>>
>>Dear all,
>>Please could you share any information you may have
>>even if just a guess.....
>>I'm looking for any information regarding
>>lipoprotein(a) [Lp(a)]atherogenity, all information's
>>I have talking about relation with CHD and it's
>>independent risk factor for CHD.
>>specifically whey or what makes Lp(a) atherogenic.
>>
>>Thank you to all
>>Have a nice weekend
>>Mohmed
>>
>>
>>
>>
>>___________________________________________________________
>>Copy addresses and emails from any email account to Yahoo! Mail -
>>quick, easy and free. http://uk.docs.yahoo.com/trueswitch2.html
>>
>>------ACB discussion List Information--------
>>This is an open discussion list for the academic and clinical
>>community working in clinical biochemistry. Please note, archived
>>messages are public and can be viewed via the internet. Views
>>expressed are those of the individual and they are responsible for all
>>message content. ACB Web Site
>>http://www.acb.org.uk
>>List Archives
>>http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
>>List Instructions (How to leave etc.)
>>http://www.jiscmail.ac.uk/
>>
>>Disclaimer:
>>
>>This e-mail and any files transmitted with it are confidential. If you
>>are not the intended recipient, any reading, printing, storage,
>>disclosure, copying or any other action taken in respect of this
>>e-mail is prohibited and may be unlawful. If you are not the intended
>>recipient, please notify the sender immediately by using the reply
>>function and then permanently delete what you have received.
>>
>>Incoming and outgoing e-mail messages are routinely monitored for
>>compliance with the Department of Health's policy on the use of
>>electronic communications. For more information on the Department of
>>Health's e-mail policy click here
>>http://www.doh.gov.uk/emaildisclaimer.htm
>>
>>------ACB discussion List Information--------
>>This is an open discussion list for the academic and clinical
>>community working in clinical biochemistry. Please note, archived
>>messages are public and can be viewed via the internet. Views
>>expressed are those of the individual and they are responsible for all
>>message content. ACB Web Site
>>http://www.acb.org.uk
>>List Archives
>>http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
>>List Instructions (How to leave etc.)
>>http://www.jiscmail.ac.uk/
>
>Prof. Andrea Rita Horvath, MD, PhD, EurClinChem, FRCPath Secretary of
>EC4 Chair of the Committee on Evidence-based Laboratory Medicine, IFCC
>President of the Hungarian Society of Laboratory Medicine
>Department of Clinical Chemistry
>University of Szeged
>Albert Szent-Gyorgyi Medical and Pharmacological Centre
>Somogyi Bela ter 1, Szeged
>H-6725, Hungary
>
>Tel: (+36)-62 545 770
>Fax: (+36)-62 544 559
>mobile: (+36)-20 332 7290
>
>------ACB discussion List Information--------
>This is an open discussion list for the academic and clinical community
>working in clinical biochemistry. Please note, archived messages are
>public and can be viewed via the internet. Views expressed are those of
>the individual and they are responsible for all message content.
>ACB Web Site
>http://www.acb.org.uk
>List Archives
>http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
>List Instructions (How to leave etc.)
>http://www.jiscmail.ac.uk/
_________________________________________________________________
Windows Live Messenger sur i-mode(tm) : dialoguez avec vos amis depuis votre
mobile comme sur PC ! http://mobile.live.fr/messenger/bouygues/
------ACB discussion List Information--------
This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/
------ACB discussion List Information--------
This is an open discussion list for the academic and clinical
community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
via the internet. Views expressed are those of the individual and
they are responsible for all message content.
ACB Web Site
http://www.acb.org.uk
List Archives
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
List Instructions (How to leave etc.)
http://www.jiscmail.ac.uk/
|