Low vitamin levels may be detected long before
clinical signs and symptoms develop. This is
especially true for vtamins that are stored at
appreciable quantities in the body such as vit D and
B12. It is also true for iron where depleted iron
stores (Grade I iron deficiency) predates the
development of microcytic hypochromic anaemia.
Mohammad
--- Jonathan Kay <[log in to unmask]> wrote:
> Paul Collinson wrote;
>
>
> > Beacuse it is a useless test for detecting low
> vitamin D. An audit of
> > 2 years
> > work at SGH shows the AUC by ROC analysis to .55 =
> toss a coin
> >
> > --
> > Paul Collinson
>
>
> Was that audit of P-ALP against serum Vitamin D
> concentration, or P-ALP
> against some clinical or biological measure of
> clinical vitamin D
> deficiency?
>
> Jonathan
>
>
> Ian Godber wrote:
>
>
> > Of cause it also depends on your cut offs. An
> audit on nearly 700
> > patients carried out when I was in Nottingham (ACB
> Focus Proc 2001
> > p39) resulted in similar findings, although we
> were testing the
> > hypothesis as to whether hypocalcaemia, raised PTH
> (>30 ng/L) and ALP
> > (>280 U/L) could be used as a surrogate measure of
> Vit D, in the
> > investigation of deficiency/insufficiency.
> >
> > Our findings showed that this test combination
> couldn't be used, as
> > 19% of subjects would be missed if Vit D
> insufficiency was defined as
> > <30 nmol/L and 11% would be missed if a Vit D of
> <22 nmol/L was used
>
> I think I'm asking if serum Vitamin D concentration
> (? on a single
> occasion, ? without regard to time of year) is a
> good enough way of
> estimating Vitamin D status and the biological
> effects of deficiency...
>
> Jonathan
>
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=====
Dr. M A Al-Jubouri
Consultant Chemical Pathologist
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------ACB discussion List Information--------
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