The Bayer statin [cerivastatin] was discontinued because it caused
rhabdomyolysis in a relatively large number of people [higher proportion
than other statins]. This occurred especially in patients taking gemfibrozil
concurrently because this intereferd with the excretion of cerivastatin,
resulting in serum concentration increased 10-fold. One theory about this is
that ceriva was the most lipid soluble statin - and therefore it has been
suggested that if it is necessary to use statin & fibrate cmbinations, the
most appropriate course is to use a water-soluble statin [prava], and soon
rosuva.
TIM
****************************************************************************
*********
Prof. Tim Reynolds,
Clinical Chemistry Department,
Queens Hospital,
Belvedere Rd.,
Burton-on-Trent,
STAFFORDSHIRE,
DE13 0RB,
UK.
tel: 01283 511511 ext. 4035
fax: 01283 593064
email: [log in to unmask]
alternative email for the all too frequent occasions when the NHS email
connection doesn't work:
[log in to unmask]
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> -----Original Message-----
> From: Mohmed Ashmaig [mailto:[log in to unmask]]
> Sent: 14 February 2003 05:18
> To: [log in to unmask]
> Subject: Re: raised CK and bladder ca
>
>
> Statin is known to raise the CK level, due to it's
> effect on muscles. In fact the statin from Bayer
> company has been stoped for the same reason.
>
> Mohmed
>
>
> --- Jeffrey Barron
> <[log in to unmask]> wrote: > A 72
> year woman with type 2 diabetes and on
> > treatment for bladder cancer
> > was screened to start on a statin. The CK was found
> > to be 255 u/L Ref
> > range 40-200. On repeat after stopping gardening and
> > normal thyroid
> > function tests, the CK was 431 u/L.
> > Tietz guide to tests states that bladder cancer is a
> > cause of raised
> > CK.
> > A search of the last 6 years of medline has no
> > association between
> > bladder cancer and raised CK.
> > I wondered if anyone has experience of this.
> >
> > Jeffrey Barron
> >
> >
> > Dr Jeffrey Barron
> > Consultant Chemical Pathologist
> > St Helier Hospital
> > Carshalton
> > Surrey SM5 1AA
> > UK
> >
> > Tel UK 20 8296 2660
> > Fax UK 20 8641 2633
> > [log in to unmask]
> >
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> > FN:Jeffrey Barron
> > TEL;WORK:020 8296 2660
> > ORG:;Chemical Pathology
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> EMAIL;WORK;PREF;NGW:[log in to unmask]
> > N:Barron;Jeffrey
> > TITLE:Consultant
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