I would hesitate to state that a study powered to show efficacy
differences would in turn be powered to show economic differences - this
is a notoriously awkward situation as, as you say, economically
significant differences are in the 'eye of the beholder'.
In my view, I strongly feel that clinical trials should be powered and
used to demonstrate clinically significant differences and these results
used in a separate economic study. I do not believe that it is reasonable
to use a clinical study for piggybacking economic studies - several
reasons: protocol restrictions; inclusion/exclusion criteria; visits, etc
different from 'real world'
Regards,
Dr Richard Phillips
The Goffin Consultancy Ltd
Riding House,
Bossingham Road
Stelling Minnis
Canterbury, Kent CT4 6AZ
United Kingdom
Tel: +44 (0)1227 709220
Fax: +44 (0)1227 709721
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Web: www.goffin-network.co.uk
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