John,
Why is it thought that acetaldehyde is responsible for the addictive aspects
of ethanol, when the basis for aversion therapy in alcoholics (disulfiram)
is based on inhibition of ALDH and production of acetaldehyde if alcohol is
ingested?
Also, individuals who are alcohol intolerant due to inherited ALDH
deficiency do not become addicted do they?
Am I missing something obvious?
Stuart Robertson
Clinical Biochemistry Dept
Hull Royal Infirmary
Hull
HU3 2JZ
> ----------
> From: Dr John A Duley[SMTP:[log in to unmask]]
> Reply To: [log in to unmask]
> Sent: 03 December 2002 18:35
> To: [log in to unmask]
> Subject: Re: alcohol intolerance
>
> ........Acetaldehyde is vasodilative and produces a
> characteristic 'flushing syndrome' (this would help for
> diagnosis of the patient).
>
> It also produces headache etc. It is thought to be
> responsible for the addictive aspects of alcohol........
>
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