The logic of using a creatinine clearance emulator intrigues me.
The purpose of measurement of clearance is to direct a clinical management
decision. If an algorithm based on serum/plasma creatinine plus other data
such as sex can be used to emulate clearance and that is then used to direct
the decision, is not one actually using a sex/racial/weight 'corrected'
function of serum/plasma creatinine to define the action limits?
Would it not, therefore, be more logical to seek direct rather than indirect
associations between serum/plasma creatinine concentration and outcome?
Trevor Tickner,
Norwich
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