I have had experience of a patient having their CA-125 rise to 135 three
days post pelvic exam and it showed a classic half life curve. She had full
gynae work up with no abnormality and is now 6 years later symptom and
disease free. I certainly think that a post op CA-125 is due to manipulation
of ovaries and should be ignored if it returned to normal. Upto 1% of normal
blood donars have a CA-125 greater than 100 and ovarian cancer is of several
orders of magnitude less is this population.
Elizabeth Mac Namara
-----Original Message-----
From: This list is an open discussion list for the academic community
workingin [mailto:[log in to unmask]]On Behalf Of Ian
Holbrook
Sent: September 18, 2001 8:18 AM
To: [log in to unmask]
Subject: CA-125 post operation
I have had a query from one of our gynaecologists about the interpretation
of some CA125 results.
A 56y old woman had a serum CA125 level of 23 kU/L (Immulite 2000)on 15th
August. On 11th September an exploratory abdominal operation was performed
to look at a cyst on her ovary. Some manipulation of ovary and peritoneum
took place during this procedure. I understand no biopsy was taken.
CA125 measured in the serum the next day was 1527 kU/L and this checked out
when repeated (we no longer had the sample taken in August to check).
The query is what is the cause of the increased CA125? Could manipulation of
peritoneum and ovary with no malignancy cause such an increase? Could the
rise be due to manipulation of malignant tissue which caused a release of a
bolus of CA125?
Has anyone any thoughts or a possible explanation?
Many thanks for your help.
Ian Holbrook
Department of Chemical Pathology
York District Hospital
UK
Wigginton Road
YORK YO31 8HE
UK
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