"glucose-6-dehydrogenase deficiency"
You could start your research here.
http://www3.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?305900#Reference365
Below is a short cutting, the full article is contained in the above
reference.
Snip------- "G6PD is in the hexose monophosphate pathway, the only
NADPH-generation process in mature red cells, which lack the citric acid
cycle. For this reason G6PD deficiency has adverse physiologic effects.
Deficiency of the red cell enzyme, in various forms, is the basis of favism,
primaquine sensitivity and some other drug-sensitive hemolytic anemias,
anemia and jaundice in the newborn, and chronic nonspherocytic hemolytic
anemia (Beutler et al., 1968). Beaconsfield et al. (1965) advanced the
hypothesis that the incidence of cancer is inversely related to the
frequency of G6PD deficiency in blacks. Since the metabolism of xylitol
remains intact in G6PD-dependent red cells, Wang et al. (1971) suggested use
of xylitol in the treatment of hemolytic crisis. Different variants of the
enzyme are found in high frequency in African, Mediterranean and Asiatic
populations (Porter et al., 1964), and heterozygote advantage vis-a-vis
malaria (Luzzatto et al., 1969) has been invoked to account for the high
frequency of the particular alleles in particular populations. The variety
of forms of the enzyme is great, as illustrated by the published tables
(Yoshida et al., 1971; Beutler and Yoshida, 1973 ; Yoshida and Beutler, 1978
and by the listing of allelic variants in this entry. The World Health
Organization (WHO, 1967) gave its attention to problems of nomenclature and
standard procedures for study. The demonstrated polymorphism at this
X-linked locus rivals that of the autosomal loci for the polypeptide chains
of hemoglobin. As in the latter instance, single amino acid substitution has
been demonstrated as the basis of the change in the G6PD molecule resulting
from mutation (Yoshida et al., 1967 ).-----"Snip
Lynda
Lynda Jackson
Senior Medical Research Analyst/Writer
Medical Education Network
mailto:[log in to unmask]
-----Original Message-----
From: Leon Lerm [mailto:[log in to unmask]]
Sent: Thursday, August 10, 2000 10:53 PM
To: [log in to unmask]
<mailto:[log in to unmask]>
Subject: G6PDD & Nitrofurantoin
I'm a general practitioner doing my honors in pharmacology and have an
assignment on the effect that nitrofurantoin has on patients with
glucose-6-dehydrogenase deficiency. I have tried to find information on the
web, however I'm still not sure what the association is between these two.
What is the evidence concerning the mechanism of hemolysis of red blood
cells?
Thank you.
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