>From the clinical point of view the better gold standard is one that
identifies people who will benefit from treatment. In reality many
diagnostic labels have fuzzy edges and in this region diagnosis can be more
a matter of semantics. E.g. the number of the infected people who get
symptoms of flu depends heavily on the definition of flu symptoms. The
tacit clinical question is often not "what is the diagnosis", but "shall I
prescribe the treatment".
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