Dear All,
* Is there to your knowledge (in analogy to the Framingham algorithm
for 'overall' CV risk) a statistical model/algorithm that takes into
account various risks factors for thrombo-embolic disease (Hct,
platelet count, plasma fibrinogen, proteins C and S, etc.) and
predicts the overall risk on thrombo-embolic disease?
* What clinical weight should be given to the routine finding of a
mild elevated platelet count (constant on repeated occasions,
probably primary) with respect to diagnosis, but more in particular
with regard to prognosis and treatment.
I took interest in this, since a patient showed up with a value of
485,000/µL, has no obvious signs of hemoconcentration, while a
limited number of standard clotting tests performed are normal (PT
Quick, APTT).
Where does one start with the introduction of platelet-aggregation-
inhibitors?
I took a quick look at the literature and some EBM-sites did't find
any paper which addresses a value that is somewhat less then
500,000/µL.
Hope you can be of any help here.
Best Regards, Hans
http://www.rug.ac.be/
________________________________
Dr Hans RJH VERSTRAELEN,MD,MPH,Ph.D.res.
Department of Public Health
University Ghent
University Hospital - 2 Blok A
De Pintelaan, 185
B-9000 Gent
Belgium (EU)
tel +32/9/240 3617 or 4589 or 3628
fax +32/9/240 5107 or 4994
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