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ACB-CLIN-CHEM-GEN  1999

ACB-CLIN-CHEM-GEN 1999

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Subject:

Re: Consultant Chemical Pathologist in Oxford

From:

Jonathan Kay <[log in to unmask]>

Reply-To:

[log in to unmask][log in to unmask], 12 Feb 1999 21:48:32 +0000390_us-ascii We were asked to do blood gases on a patient after a standard tread-mill
exercise test and were surprised to find that the blood pH was 7.05. We
have not been able to find out whether this is a 'normal' response to
exercise. Does anyone have information on what changes in pH and blood
gases are expected in a untrained middle-aged male after aerobic
exercise. [...]49_12Feb199921:48:[log in to unmask] 5918 33 37_Re: blood ph and gases after exercise11_Nick [log in to unmask], 13 Feb 1999 09:11:04 -0000343_US-ASCII I don't have any reference ranges for you, but in my experience, based
on a student project in the lab, you can easily reduce the blood pH
in a healthy individual to 7.05 by exercise. However, it returns to
7.40 as the person recovers - and that is what distinguishes them
from someone with an acid-base disturbance. [...]42_13Feb199909:11:[log in to unmask] 5952 29 19_Case 52 for [log in to unmask], 15 Feb 1999 10:30:32 -0000438_ISO-8859-1 Thanks to Waise Ahmed for suggesting this case.

A 61 year old man, seeing his Family Doctor.
The serum PSA was 7.6 ug/L (Abbott IMX, reference range up to 4 ug/L). The
clinical information is 'raised PSA'.

Previous results on this patient were
6.7 ug/L, 9 months previously
5.7 ug/L, 16 months previously
5.4 ug/L, 23 months previously. The clinical information then was 'mild
prostatism'. [...]47_15Feb199910:30:[log in to unmask] 5982 39 16_VANCOMYCIN ASSAY12_John [log in to unmask], 16 Feb 1999 18:05:12 +1000643_- When comparing vancomycin results from an Abbott TDxFLx and an
Abbott AXSYM. we came across marked discrepancies in a patient with
liver disease. He had a very high bilirubin, with most being conjugated
(>300 umol/L). The results in mg/L from the two assays were as folows:
TDX AXSYM
2.6 8.0
15.3 24.1
14.4 20.2
Since then, we have noted lower results by the TDX assay in another
two patients with liver disease and conjugated hyperbilirubinaemia,
although not as marked differences as those above. We have also
obtained plasma from the above patient when he was not receiving
vancomycin plus two [...]39_16Feb199918:05:[log in to unmask] 6022 27 21_Re: Vancomycin Assays12_Graham [log in to unmask], 16 Feb 1999 18:53:48 +1100543_us-ascii John,

I note with interest your problem with Vancomycin on the TDx in patients
with severe liver disease. I am reminded of some studies we did many years
ago into DLIS in these patients. As well as measuring some digoxin
immunoreactive material, there was a change in the background seen on the
TDx instrument. It may be valuable to look at the raw data from the
instrument as I suspected at the time (as I say many years ago) that there
was something that interfered non-specifically in the TDx system. [...]46_16Feb199918:53:[log in to unmask] 6050 1520 24_Clinical chemistry sites11_R.W. [log in to unmask], 16 Feb 1999 10:09:42 +0100586_US-ASCII Dear collegue,

Much like a squirrel collecting nuts when the winds get chilly,
I have made a collection of addresses referring to clinical
chemistry sites on the Internet. You will find it in the attachment
(WORDS97).
Just as most sites have a possibility to click on "useful links",
I think we should have a quick reference list of our own in clinical
chemistry. This would save our collegues a lot of time of tedious
browsing on the Net.
I would be interested to know what collections already have been made
by our collegues. [...]50_16Feb199910:09:[log in to unmask]

Date:

Fri, 17 Dec 1999 18:46:58 +0000

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (40 lines)

Wrong fax number in the previous email. (But that's not as bad as the BMJ
calling it "Clinical Pathology"!)

Jonathan

The fax number should be:
01865 220348

Jonathan Kay wrote:

> OXFORD RADCLIFFE HOSPITALS NHS TRUST
>
> CONSULTANT
>
> CHEMICAL PATHOLOGY
>
> Applications are invited for a Consultant in Chemical Pathology. The
> post is primarily based at the John Radcliffe but carries
> responsibilities at the other Oxford hospitals and at the Horton
> Hospital, Banbury. The postholder will also undertake outpatient
> sessions in Metabolic Medicine. The appointment is on a whole
> time/maximum part time basis but applications are welcome from those who
> wish to job share.
>
> To obtain further details please contact the Medical Staffing
> Department, Oxford Radcliffe Hospitals NHS Trust, Manor House, Headley
> Way, Headington, Oxford OX3 9DZ, telephone Oxford (01865) 222140 (24
> hour answering service), quoting reference S5388. Closing date for
> receipt of applications: January 14 2000.
>
> ...............
>
> Dr Jonathan Kay
> [log in to unmask]
> 'Phone: 01865 220470
> Fax: 01865 220348


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